One-step ahead adaptive D-optimal design on a finite design space is asymptotically optimal
نویسندگان
چکیده
منابع مشابه
One-step ahead adaptive D-optimal design on a finite design space is asymptotically optimal
We study the consistency of parameter estimators in adaptive designs generated by a onestep ahead D-optimal algorithm. We show that when the design space is finite, under mild conditions the least-squares estimator in a nonlinear regression model is strongly consistent and the information matrix evaluated at the current estimated value of the parameters strongly converges to the D-optimal matri...
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The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...
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ژورنال
عنوان ژورنال: Metrika
سال: 2009
ISSN: 0026-1335,1435-926X
DOI: 10.1007/s00184-008-0227-y